1. [n]  a residential part of town away from the central commercial district
2. [adv]  toward or in the upper part of town
3. [adj]  of or located in the upper part of a town; "uptown residential areas"

UPTOWN is a 6 letter word that starts with U.

1. \Up*town"\, adv.
   To or in the upper part of a town; as, to go uptown. [Colloq.
   U. S.]
   
   

2. \Up"town`\, a.
   Situated in, or belonging to, the upper part of a town or
   city; as, a uptown street, shop, etc.; uptown society.
   [Colloq. U. S.]