1. [n]  a naval battle in the Spanish-American War (1898); the United States fleet bottled up the Spanish ships in the harbor of Santiago de Cuba and destroyed them when they tried to escape
2. [n]  the capital and largest city of Chile; located in central Chile; one of the largest cities in South America
3. [n]  port city in southeastern Chile; industrial center
4. [n]  city in the northern Dominican Republic

SANTIAGO is a 8 letter word that starts with S.